A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.
Change log
Authors
Ingham, Richard J
Battilocchio, Claudio https://orcid.org/0000-0002-4601-8527
Fitzpatrick, Daniel E
Sliwinski, Eric
Hawkins, Joel M
Abstract
Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.
Description
Keywords
continuous processing, flow reactors, integrated systems, synthetic methods, Amantadine, Carboxylic Acids, Chemistry Techniques, Synthetic, Equipment Design
Journal Title
Angew Chem Int Ed Engl
Conference Name
Journal ISSN
1433-7851
1521-3773
1521-3773
Volume Title
54
Publisher
Wiley
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
The authors gratefully acknowledge support from Ralph Raphael
Scholarship (RJI), Woolf Fisher Trust (DEF), UK Engineering
and Physical Sciences Research Council (ES and SVL) and
Pfizer Worldwide Research and Development (CB and JMH).