Activin/Nodal signalling in stem cells.
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Authors
Pauklin, Siim
Vallier, Ludovic https://orcid.org/0000-0002-3848-2602
Abstract
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.
Description
Keywords
Activin, Cell cycle, Differentiation, Nodal, Pluripotency, Stem cells, Activins, Animals, Cell Differentiation, Humans, Nodal Protein, Pluripotent Stem Cells, Signal Transduction, Stem Cells
Journal Title
Development
Conference Name
Journal ISSN
0950-1991
1477-9129
1477-9129
Volume Title
142
Publisher
The Company of Biologists
Publisher DOI
Sponsorship
Medical Research Council (G1000847)
Medical Research Council (G0800784)
Medical Research Council (G0701448)
European Research Council (281335)
Wellcome Trust (097922/Z/11/B)
Medical Research Council (G0800784)
Medical Research Council (G0701448)
European Research Council (281335)
Wellcome Trust (097922/Z/11/B)
S.P. was supported by the EUFP7 grant InnovaLIV and an FEBS long-term fellowship. L.V. was supported by the ERC starting grant Relieve IMDs and the Cambridge Hospitals National Institute for Health Research Biomedical Research Centre.