The cancer which survived: insights from the genome of an 11000 year-old cancer.
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Authors
Strakova, Andrea https://orcid.org/0000-0001-6221-5515
Murchison, Elizabeth P
Abstract
The canine transmissible venereal tumour (CTVT) is a transmissible cancer that is spread between dogs by the allogeneic transfer of living cancer cells during coitus. CTVT affects dogs around the world and is the oldest and most divergent cancer lineage known in nature. CTVT first emerged as a cancer about 11000 years ago from the somatic cells of an individual dog, and has subsequently acquired adaptations for cell transmission between hosts and for survival as an allogeneic graft. Furthermore, it has achieved a genome configuration which is compatible with long-term survival. Here, we discuss and speculate on the evolutionary processes and adaptions which underlie the success of this remarkable lineage.
Description
Keywords
Animals, Dog Diseases, Dogs, Neoplasms, Tumor Escape
Journal Title
Curr Opin Genet Dev
Conference Name
Journal ISSN
0959-437X
1879-0380
1879-0380
Volume Title
30
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (102942/Z/13/Z)
We thank Máire Lawlor for helpful discussions and critical reading of the manuscript. This work is supported by a grant from the Wellcome Trust (102942/Z/13/A), a grant from the National Science Foundation (DEB-1316549), a Royal Society Research Grant (RG130615), an Eric Guiler Tasmanian Devil Research Grant from the University of Tasmania Foundation and a Philip Leverhulme Prize awarded by the Leverhulme Trust.