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Preparation and Supramolecular Recognition of Multivalent Peptide-Polysaccharide Conjugates by Cucurbit[8]uril in Hydrogel Formation.


Type

Article

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Authors

Rowland, Matthew J 
Atgie, Marina 
Hoogland, Dominique  ORCID logo  https://orcid.org/0000-0002-1655-2833
Scherman, Oren A 

Abstract

Supramolecular hydrogels were fabricated by physically cross-linking phenylalanine functionalized polysaccharides with cucurbit[8]uril in water. We report a facile 2-step method of functionalization of the polysaccharides hyaluronic acid (HA), carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), and guar with the dipeptide Phe-Cys. Addition of cucurbit[8]uril to the functional polysaccharides initiated physical cross-linking on account of strong 1:2 "homoternary" complexes with the pendant Phe residues. In particular, HA and CMC based soft hydrogels displayed impressive viscoelastic behavior which was characterized using rheology, demonstrating accessibility to an array of material properties which would find broad applicability in many fields.

Description

Keywords

Carboxymethylcellulose Sodium, Dipeptides, Hyaluronic Acid, Hydrogels, Macrocyclic Compounds, Phenylalanine, Polysaccharides, Rheology, Water

Journal Title

Biomacromolecules

Conference Name

Journal ISSN

1525-7797
1526-4602

Volume Title

16

Publisher

American Chemical Society (ACS)
Sponsorship
European Research Council (240629)
M.J.R. thanks the University of Cambridge Chemical Biology and Molecular Medicine PhD Training Programme for funding. OAS thanks ERC Starting Investigator Grant (ASPiRe). The authors would also like to thank Silvia Sonzini for her assistance with collecting ITC data.