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A multimodal approach to dementia prevention: A report from the Cambridge Institute of Public Health.

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Peer-reviewed

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Article

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Authors

Olanrewaju, Olawale 
Clare, Linda 

Abstract

INTRODUCTION: Globally, dementia is the most frequent form of degenerative condition in the older adult population and poses a major health burden with high socioeconomic costs. So far, attempts to find pharmacologic interventions that can change the onset or progression of dementia have been largely unsuccessful, prompting a shift to focus on interventions aimed at modifying risk factors that occur throughout the life course. METHODS: The Cognitive Function and Ageing Studies, funded by the Medical Research Council, UK, convened three multidisciplinary groups of experts, expert witnesses, and advocates to discuss the state of evidence on primary, secondary, and tertiary dementia prevention and recommend future direction for intervention studies. RESULTS: Using the United Kingdom Parliamentary Select Committees' approach to gathering evidence, the primary prevention working group focused their deliberation on risk factors strongly associated with dementia. The group highlighted the need for high-quality studies to assess the effects of behavioral intervention on the delay of cognitive decline and dementia onset. DISCUSSION: The working group recommended that the development of a future dementia prevention trial should use a multimodal, multifactor, multilevel, community and individually tailored approach.

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Keywords

Aging, Cognitive decline, Dementia, Expert review, Non-pharmacological intervention, Preventive health

Journal Title

Alzheimers Dement (N Y)

Conference Name

Journal ISSN

2352-8737
2352-8737

Volume Title

1

Publisher

Wiley
Sponsorship
Medical Research Council (G0601022)
Medical Research Council (G9901400)
The CFAS expert workshop on Dementia Prevention was funded by the Medical Research Council, United Kingdom. The MRC CFAS-I study is supported by major awards from the Medical Research Council (Research Grant [G9901400]) and the UK Department of Health. The MRC CFAS-II is supported by major awards from the Medical Research Council (Research Grant [G0601022]), support from the National Institute for Health Research (NIHR) comprehensive clinical research networks (CLRN’s) in West Anglia and Trent, and the Dementias and Neurodegenerative Disease Research Network (DeNDRoN) in Newcastle. CFAS is a member of the collaboration for leadership in applied health research and care for the east of England (CLAHRC EoE), the Cambridge Biomedical Research Centre infrastructures, Nottingham City and Nottinghamshire County NHS Primary care trusts, and the UK NIHR Biomedical Research centre for ageing and age-related disease award to Newcastle-Upon-Tyne hospital foundation trust.