Research Data - Pharmacology
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Item Open Access Research data supporting 'Digging deeper into pain – an ethological behavior assay correlating well-being in mice with human pain experience.'Pattison, Luke A; Smith, Ewan St JohnItem Open Access Research data supporting "KV7 but not dual SK/IK channel openers inhibit the activation of colonic afferents by noxious stimuli"Bhebhe, Charity; Higham, James; Gupta, Rohit; Raine, Tim; Bulmer, DavidItem Open Access Research Data File relating to the effect of chemokine receptor expression on receptor activity modifying protein expressionHarris, Matthew; Ladds, Graham; Harris, Matthew [0000-0002-7918-5735]; Ladds, Graham [0000-0001-7320-9612]Item Open Access Research Data supporting "Biosensor for Multimodal Characterization of an Essential ABC Transporter for Next-Generation Antibiotic Research"Bali, Karan; Guffick, Charlotte; McCoy, Reece; Lu, Zixuan; Kaminski, Clemens; Mela, Ioanna; Owens, Roisin; Van Veen, Hendrik W; Van Veen, Hendrik W. [0000-0002-9658-8077]Item Open Access Research data supporting: "Dysregulation of ADAM10 shedding activity in naked mole-rat fibroblasts is due to deficient phosphatidylserine externalisation"Smith, Ewan; Smith, Ewan [0000-0002-2699-1979]Item Open Access Research data supporting "Sensitisation of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity"Barker, Katie; Higham, James; Pattison, Luke; Taylor, Toni; Chessell, Iain; Welsh, Fraser; Smith, Ewan; Bulmer, David; Barker, Katie [0000-0002-8601-4416]; Smith, Ewan [0000-0002-2699-1979]; Bulmer, David [0000-0002-4703-7877]Item Open Access Research data supporting "Drug-dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from Streptococcus pneumoniae"Guffick, Charlotte; Hsieh, Pei-Yu; Ali, Anam; Shi, Wilma; Howard, Julie; Chinthapalli, Dinesh K; Kong, Alex C; Salaa, Ihsene; Crouch, Lucy I; Ansbro, Megan R; Isaacson, Shoshanna C; Singh, Himansha; Barrera, Nelson P; Nair, Asha V; Robinson, Carol V; Deery, Michael J; Van Veen, Hendrik WItem Open Access Research data supporting "Energetics of lipid transport by the ABC transporter MsbA is lipid dependent"Guo, Dawei; Singh, Himansha; Shimoyama, Atsushi; Guffick, Charlotte; Tang, Yakun; Rowe, Sam M; Noel, Timothy; Spring, David R; Fukase, Koichi; Van Veen, Hendrik W; Noel, Timothy [0000-0001-8081-743X]; Spring, David [0000-0001-7355-2824]Item Open Access Data to support: Functional characterization of ovine dorsal root ganglion neurons reveals peripheral sensitization after osteochondral defectChakrabarti, Sampurna; Ai, Minji; Wong, Katherine; Newell, Karin; Henson, Frances; Smith, Ewan; Ai, Minji [0000-0002-0614-5265]; Henson, Frances [0000-0002-3518-1492]; Smith, Ewan [0000-0002-2699-1979]Item Open Access Research data supporting "Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae"Raturi, Sagar; Nair, Asha V; Shinoda, Keiko; Singh, Himansha; Bai, Boyan; Murakami, Satoshi; Fujitani, Hideaki; Van Veen, Hendrik W; Van Veen, Hendrik W. [0000-0002-9658-8077]Item Open Access Research data supporting 'Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP'Swain, Brendan M; Guo, Dawei; Singh, Himansha; Rawlins, Philip B; McAlister, Mark; Van Veen, Hendrik W; Van Veen, Hendrik W. [0000-0002-9658-8077]Item Open Access Data supporting "Modes of action of the archaeal Mre11-Rad50 DNA-repair complex revealed by Fast-scan atomic force microscopy"Henderson, Robert; Zabolotnaya, Ekaterina; Mela, Ioanna; Robinson, Nicholas; Edwardson, John; Bray, Sian; Yau, Siu Kei; Papatziamou, Dmitra; Henderson, Robert [0000-0001-6583-1858]; Mela, Ioanna [0000-0002-2914-9971]Item Open Access Data to support: Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain.Chakrabarti, Sampurna; Pattison, Luke; Bhebhe, Charity; Callejo, Gerard; Bulmer, David; Smith, Ewan; Bulmer, David [0000-0002-4703-7877]; Smith, Ewan [0000-0002-2699-1979]Item Open Access Data to support: Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in miceChakrabarti, Sampurna; Pattison, Luke; Doleschall, Balint; Rickman, Rebecca; Blake, Helen; Callejo, Gerard; Heppenstall, Paul; Smith, Ewan; Smith, Ewan St John [0000-0002-2699-1979]Item Open Access Data to support: Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuliTaylor, Toni; Konda, Parvesh; John, Sarah; Bulmer, David; Hockley, James; Smith, Ewan; Bulmer, David [0000-0002-4703-7877]; Smith, Ewan St John [0000-0002-2699-1979]Item Open Access Data to support: In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3Smith, Ewan; Smith, Ewan St John [0000-0002-2699-1979]Item Open Access Data to support: Naked mole-rat brain neurons are resistant to acid-induced cell deathSmith, ESJ; Smith, Ewan St John [0000-0002-2699-1979]Item Open Access Data to support: Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic painChakrabarti, Sampurna; Jadon, Deepak; Bulmer, David; Smith, Ewan; Chakrabarti, Sampurna [0000-0002-2750-3877]; Jadon, Deepak [0000-0003-0600-4566]; Bulmer, David [0000-0002-4703-7877]; Smith, Ewan [0000-0002-2699-1979]Item Open Access Data to support: 5-oxoETE triggers nociception in constipation predominant irritable bowel syndrome through MAS-related G protein coupled receptor DSmith, ESJ; Smith, Ewan St John [0000-0002-2699-1979]Item Open Access Research data supporting: Single-cell RNAseq reveals seven classes of colonic sensory neuronSmith, ESJ; Smith, Ewan St John [0000-0002-2699-1979]