Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Change log
Authors
Pell, Victoria R
Chouchani, Edward T
Murphy, Michael P
Brookes, Paul S
Krieg, Thomas https://orcid.org/0000-0002-5192-580X
Abstract
Mitochondrial reactive oxygen species production has emerged as an important pathological mechanism in myocardial ischemia/reperfusion injury. Attempts at targeting reactive oxygen species by scavenging using antioxidants have, however, been clinically disappointing. This review will provide an overview of the current understanding of mitochondrial reactive oxygen species in ischemia/reperfusion injury. We will outline novel therapeutic approaches designed to directly target the mitochondrial respiratory chain and prevent excessive reactive oxygen species production and its associated pathology. This approach could lead to more effective interventions in an area where there is an urgent need for new treatments.
Description
Keywords
antioxidants, mitochondria, oxygen, reactive oxygen species, reperfusion injury, Animals, Cardiovascular Agents, Drug Delivery Systems, Humans, Myocardial Infarction, Myocardial Reperfusion Injury, Reactive Oxygen Species
Journal Title
Circ Res
Conference Name
Journal ISSN
0009-7330
1524-4571
1524-4571
Volume Title
118
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
Sponsorship
British Heart Foundation (None)
Medical Research Council (MC_U105663142)
Medical Research Council (MC_U105663142)
Work in our laboratories is supported by the Medical Research Council (UK) and the British Heart Foundation.