Old cells, new tricks: chromatin structure in senescence.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Parry, Aled John
Narita, Masashi https://orcid.org/0000-0001-7764-577X
Abstract
Cellular senescence is a stable form of cell cycle arrest with roles in many pathophysiological processes including development, tissue repair, cancer, and aging. Senescence does not represent a single entity but rather a heterogeneous phenotype that depends on the trigger and cell type of origin. Such heterogeneous features include alterations to chromatin structure and epigenetic states. New technologies are beginning to unravel the distinct mechanisms regulating chromatin structure during senescence. Here, we describe the multiple levels of chromatin organization associated with senescence: global and focal, linear, and higher order.
Description
Keywords
Aging, Animals, Cellular Senescence, Chromatin, Epigenesis, Genetic, Genome, Human, Heterochromatin, Humans
Journal Title
Mamm Genome
Conference Name
Journal ISSN
0938-8990
1432-1777
1432-1777
Volume Title
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Cancer Research UK (C14303/A17197)
The University of Cambridge, Cancer Research UK and Hutchison Whampoa supported this work.