We demonstrate the feasibility of a 16 × 3.75 Gb/s (60 Gb/s aggregate) Orthogonal frequency division multiplexing-code division multiple access passive optical network for next-generation access applications. 3.75 Gb/s PON channel transmission over 25 km single-mode fiber shows 0.1 dB dispersion and 0.9 dB crosstalk penalties. Advantages of the system include high capacity, enhanced spectral efficiency, coding gain, and networking functions such as increased security and single-wavelength operation.