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Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Siebald, Caroline 
Khandaker, Golam M 
Zammit, Stanley 
Lewis, Glyn 
Jones, Peter B 

Abstract

BACKGROUND: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. METHOD: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8years. IQ was assessed by WISC-III also at 8years. PEs, depressive and anxiety symptoms were assessed at 13years. Logistic regression calculated odds ratio (OR) for PEs at 13years associated with psychiatric disorders at 8years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. RESULTS: In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ -6.17 (95% CI, -7.86, -4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47-2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8years and depressive and anxiety symptoms at 13years. CONCLUSIONS: The findings indicate that adolescent PEs are associated with general cognitive ability and past and present psychopathological factors.

Description

Keywords

Adolescent, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Child, Child Development Disorders, Pervasive, Conduct Disorder, Depression, Female, Humans, Intelligence, Longitudinal Studies, Male, Prospective Studies, Psychotic Disorders

Journal Title

Compr Psychiatry

Conference Name

Journal ISSN

0010-440X
1532-8384

Volume Title

Publisher

Elsevier BV
Sponsorship
National Institute for Health Research (NIHR) (via Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (unknown)
Academy of Medical Sciences (unknown)
Wellcome Trust (088869/Z/09/Z)
Wellcome Trust (095844/Z/11/Z)
Wellcome Trust (093875/Z/10/Z)
National Institute for Health and Care Research (RP-PG-0606-1335)
Medical Research Council (G0701503)
Prof Jones acknowledges support from the Wellcome Trust (095844/Z/11/Z & 088869/Z/09/Z) and NIHR (RP-PG-0606-1335). The UK Medical Research Council and the Wellcome Trust grant ref. 092731 and the University of Bristol provide core support for the ALSPAC cohort.