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Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

Published version
Peer-reviewed

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Authors

Serrao, Eva M 
Gallagher, Ferdia A 
Kennedy, Brett WC 

Abstract

Imaging of the metabolism of hyperpolarized [1-(13) C]pyruvate has shown considerable promise in preclinical studies in oncology, particularly for the assessment of early treatment response. The repeatability of measurements of (13) C label exchange between pyruvate and lactate was determined in a murine lymphoma model in fasted and non-fasted animals. The fasted state showed lower intra-individual variability, although the [1-(13) C]lactate/[1-(13) C]pyruvate signal ratio was significantly greater in fasted than in non-fasted mice, which may be explained by the higher tumor lactate concentrations in fasted animals. These results indicate that the fasted state may be preferable for the measurement of (13) C label exchange between pyruvate and lactate, as it reduces the variability and therefore should make it easier to detect the effects of therapy. © 2016 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

Description

Keywords

cancer, fasting, hyperpolarization, lymphoma, pyruvate, repeatability, Algorithms, Animals, Biomarkers, Tumor, Carbon-13 Magnetic Resonance Spectroscopy, Fasting, Female, Mice, Mice, Inbred C57BL, Neoplasms, Experimental, Pyruvic Acid, Reproducibility of Results, Sensitivity and Specificity, Signal Processing, Computer-Assisted

Journal Title

NMR Biomed

Conference Name

Journal ISSN

0952-3480
1099-1492

Volume Title

29

Publisher

Wiley
Sponsorship
Cancer Research Uk (None)
Cancer Research UK (CB4100)
Cancer Research UK (C14303/A17197)
Cancer Research Uk (None)
European Commission (264780)
Cancer Research UK (Grant ID: 17242)