DNA brick self-assembly with an off-lattice potential.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Reinhardt, Aleks
Frenkel, Daan https://orcid.org/0000-0002-6362-2021
Abstract
We report Monte Carlo simulations of a simple off-lattice patchy-particle model for DNA 'bricks'. We relate the parameters that characterise this model with the binding free energy of pairs of single-stranded DNA molecules. We verify that an off-lattice potential parameterised in this way reproduces much of the behaviour seen with a simpler lattice model we introduced previously, although the relaxation of the geometric constraints leads to a more error-prone self-assembly pathway. We investigate the self-assembly process as a function of the strength of the non-specific interactions. We show that our off-lattice model for DNA bricks results in robust self-assembly into a variety of target structures.
Description
Keywords
DNA, DNA, Single-Stranded, Monte Carlo Method
Journal Title
Soft Matter
Conference Name
Journal ISSN
1744-683X
1744-6848
1744-6848
Volume Title
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/I001352/1)
This work was supported by the Engineering and Physical Sciences Research Council [Programme Grant EP/I001352/1]. Research carried out in part at the Center for Functional Nanomaterials, Brookhaven National Laboratory, which is supported by the US Department of Energy, Office of Basic Energy Sciences, under Contract No. DE-SC0012704.