LILRA6 copy number variation correlates with susceptibility to atopic dermatitis.
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Peer-reviewed
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Authors
López-Álvarez, MR
Jones, DC
Jayaraman, J
Johnson, C
Abstract
Leukocyte immunoglobulin-like receptors (LILR) are expressed mostly on myelomonocytic cells where they are mediators of immunological tolerance. Two LILR genes, LILRA3 and LILRA6, exhibit marked copy number variation. We assessed the contribution of these genes to atopic dermatitis (AD) by analysing transmission in 378 AD families. The data indicated that copies of LILRA6 were over-transmitted to affected patients. They are consistent with a contribution of LILR genes to AD. They could affect the equilibrium between activating and inhibitory signals in the immune response.
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Keywords
AD, Atopic dermatitis, CNV, LILR, Child, DNA, DNA Copy Number Variations, Dermatitis, Atopic, Disease Susceptibility, Female, Humans, Male, Polymerase Chain Reaction, Receptors, Immunologic
Journal Title
Immunogenetics
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Journal ISSN
0093-7711
1432-1211
1432-1211
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Publisher
Springer Science and Business Media LLC
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Worldwide Cancer Research (None)
This work was funded by the Medical Research Council (MRC) and Association for International Cancer Research (AICR) with additional support from the Wellcome Trust and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. María Rocío López-Álvarez was funded by Ministerio de Educación of Spain, under the programme "Programa Nacional de Movilidad de Recursos Humanos del Plan Nacional de I-D+i 2008-2011" and Fundación Séneca 04087/GERM/06 Project.