Tuned mass dampers (TMDs) are effective structural vibration control devices. However, very little research is available on the experimental investigation of TMDs and their performance in systems undergoing dynamic soil-structure interaction (SSI). Geotechnical centrifuge tests are conducted to investigate storey positioning effects of single and multiple TMDs in a soil-MDOF-structure system. The criteria for optimal storey positioning will be established and it is shown that storey positioning influences TMD performance more than the number of TMDs used. Non-optimal storey positioning was found to have the potential of reducing damping efficiency, amplifying peak structural response and inducing lengthier high-intensity motion.