$\textit{Drosophila}$ vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes
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Peer-reviewed
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Abstract
Vinculin is a highly conserved protein involved in cell adhesion and mechanotransduction, and both gain and loss of its activity causes defective cell behaviour. Here, we examine how altering vinculin activity perturbs integrin function within the context of
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1477-9137
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Biotechnology and Biological Sciences Research Council (BB/D526102/1)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (086451/Z/08/Z)
Cancer Research Uk (None)