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Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor

Accepted version
Peer-reviewed

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Type

Article

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Authors

Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Lau, SH 
Hawkins, JM 
Ley, SV 

Abstract

A procedure that yields pyrazinamide as a fine white powder is presented. A glass column reactor is used containing Celite and manganese dioxide and is mounted vertically in a heating jacket. Following the procedure are notes on the instruments and chemicals used and required. The chapter concludes with a discussion on the general concepts regarding preparation of pyrazinamide.

Description

Keywords

flow chemistry, nitrile hydration, catalysis

Journal Title

Organic Syntheses

Conference Name

Journal ISSN

0078-6209
1600-0730

Volume Title

94

Publisher

Organic Syntheses Inc.
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
We are grateful to Pfizer Worldwide Research and Development (CB), the Croucher Foundation and Cambridge Trust (SHL) and the EPSRC (SVL, grant n° EP/K009494/1 and EP/M004120/1) for financial support.