Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor
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Peer-reviewed
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Abstract
A procedure that yields pyrazinamide as a fine white powder is presented. A glass column reactor is used containing Celite and manganese dioxide and is mounted vertically in a heating jacket. Following the procedure are notes on the instruments and chemicals used and required. The chapter concludes with a discussion on the general concepts regarding preparation of pyrazinamide.
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Keywords
flow chemistry, nitrile hydration, catalysis
Journal Title
Organic Syntheses
Conference Name
Journal ISSN
0078-6209
1600-0730
1600-0730
Volume Title
94
Publisher
Organic Syntheses Inc.
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Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
We are grateful to Pfizer Worldwide Research and Development (CB), the Croucher Foundation and Cambridge Trust (SHL) and the EPSRC (SVL, grant n° EP/K009494/1 and EP/M004120/1) for financial support.