Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-$^{13}$C] Dehydroascorbic Acid Reduction Using $^{13}$C Magnetic Resonance Spectroscopy
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Rapid cancer cell proliferation promotes the production of reducing equivalents, which counteract the effects of relatively high levels of reactive oxygen species (ROS). ROS levels increase in response to chemotherapy and cell death while an increase in antioxidant capacity can confer resistance to chemotherapy and is associated with an aggressive tumor phenotype. The pentose phosphate pathway (PPP) is a major site of NADPH production in the cell, which is used to maintain the main intracellular antioxidant, glutathione, in its reduced state. Previous studies have shown that the rate of hyperpolarized [1-
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1083-351X
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Cancer Research UK (CB4100)
Cancer Research UK (C14303/A17197)
European Commission (264780)