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Inflammation and infection in human cocaine addiction

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Ersche, KD 
Döffinger, R 

Abstract

Over the past 30 years, the effects of cocaine on the immune system have been subject to research mainly in animals, while relatively little work has been done in humans. This review focuses exclusively on the human work and the related findings in a way that is accessible to neuroscientists. The emerging picture suggests that cocaine may exert some direct effects on lymphocyte responses, as well as, and possibly more importantly, indirect effects via interactions with the sympathetic and neuroendocrine systems. Given the pressing need for more effective treatments for cocaine addiction and the high prevalence of medical complications associated with this disorder, this review leaves no doubt that drug addiction merits a place in the growing field of neuropsychoimmunology.

Description

Keywords

5202 Biological Psychology, 3214 Pharmacology and Pharmaceutical Sciences, 32 Biomedical and Clinical Sciences, 52 Psychology, Drug Abuse (NIDA only), Neurosciences, Brain Disorders, Substance Misuse, 6 Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Mental health, 3 Good Health and Well Being

Journal Title

Current Opinion in Behavioral Sciences

Conference Name

Journal ISSN

2352-1546
2352-1546

Volume Title

13

Publisher

Elsevier
Sponsorship
Our work described in this article was funded by the NIHR Cambridge Biomedical Research Centre.