Some Synonymous and Nonsynonymous $\textit{gyrA}$ Mutations in $\textit{Mycobacterium tuberculosis}$ Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays
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Peer-reviewed
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Abstract
We demonstrated that some non-synonymous and synonymous mutations in
Description
Keywords
$\textit{Mycobacterium tuberculosis}$, Hain GenoType MTBDRsl, fluoroquinolones
Journal Title
Antimicrobial Agents and Chemotherapy
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Journal ISSN
0066-4804
1098-6596
1098-6596
Volume Title
61
Publisher
American Society for Microbiology
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Wellcome Trust (098600/Z/12/Z)
National Institute for Health and Care Research (HICF-T5-342)
National Institute for Health and Care Research (HICF-T5-342)
T.M.W. is a University of Oxford National Institute for Health Research (NIHR) academic clinical lecturer. N.A. was supported by a doctoral study fund from Colciencias. T.S. was supported by grants from the Swedish Heart and Lung Foundation and the Marianne and Marcus Wallenberg Foundation. F.C. was supported by the Wellcome Trust (grant 201344/Z/16/Z). D.W.C. and T.E.A.P. are NIHR senior investigators supported by the NIHR Oxford Biomedical Research Centre, NIHR Oxford Health Protection Research Unit on Healthcare Associated Infection and Antimicrobial Resistance (grant HPRU-2012-10041), and the Health Innovation Challenge Fund (grant T5-358). S.N. was supported by grants from the German Center for Infection Research (DZIF), the European Union TB-PAN-NET (grant FP7-223681), and PathoNgenTrace (grant 278864). S.J.P. was supported by the Health Innovation Challenge Fund (grants HICF-T5-342 and WT098600), a parallel funding partnership between the UK Department of Health and Wellcome Trust. C.U.K. is a junior research fellow at Wolfson College, Cambridge.