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Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

Published version
Peer-reviewed

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Authors

Castanys-Muñoz, E 
Kennedy, K 
Castañeda-Gutiérrez, E 
Forsyth, S 
Godfrey, KM 

Abstract

We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affect neurodevelopment and metabolic outcomes in term-born small-for-gestational-age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure (BP), but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and BP. Conclusion: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants.

Description

Keywords

adiposity, insulin resistance, neurodevelopment, postnatal growth, small for gestational age

Journal Title

Acta Paediatrica

Conference Name

Journal ISSN

0803-5253
1651-2227

Volume Title

106

Publisher

Wiley
Sponsorship
Medical Research Council (MC_UU_12015/2)
Medical Research Council (MC_UU_12012/4)
Medical Research Council (MC_PC_12012)
The expert group received funding from the ILSI Europe Early Nutrition and Long-Term Health (formerly Metabolic Imprinting) Task Force.