Palladium-Catalyzed Enantioselective C-H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Smalley, AP
Cuthbertson, JD
Gaunt, MJ
Abstract
The design of an enantioselective Pd(II)-catalyzed C-H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the conversion of readily available amines into synthetically valuable aziridines in high enantiomeric ratios. The aziridines can be derivatized to afford a range of chiral amine building blocks incorporating motifs readily encountered in pharmaceutically relevant molecules.
Description
Keywords
0306 Physical Chemistry (incl. Structural)
Journal Title
Journal of the American Chemical Society
Conference Name
Journal ISSN
0002-7863
1520-5126
1520-5126
Volume Title
139
Publisher
American Chemical Society
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/I00548X/1)
European Research Council (259711)
European Research Council (259711)