Terminating the replication helicase.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Gaggioli, Vincent
Abstract
A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.
Description
Keywords
Adenosine Triphosphatases, Cell Cycle Proteins, DNA Helicases, DNA Replication, Ubiquitin
Journal Title
Nat Cell Biol
Conference Name
Journal ISSN
1465-7392
1476-4679
1476-4679
Volume Title
19
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Worldwide Cancer Research (formerly AICR) (10-0908)
Wellcome Trust (107056/Z/15/Z)
Wellcome Trust (107056/Z/15/Z)