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Reconstructing the gradient source position from steady-state fluxes to small receptors

Published version
Peer-reviewed

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Authors

Dobramysl, Uli 
Holcman, David 

Abstract

Recovering the position of a source from the fluxes of diffusing particles through small receptors allows a biological cell to determine its relative position, spatial localization and guide it to a final target. However, how a source can be recovered from point fluxes remains unclear. Using the Narrow Escape Time approach for an open domain, we compute the diffusion fluxes of Brownian particles generated by a steady-state gradient from a single source through small holes distributed on a surface in two dimensions. {We find that the location of a source can be recovered when there are at least 3 receptors and the source is positioned no further than 10 cell radii away}, but this condition is not necessary in a narrow strip. The present approach provides a computational basis for the first step of direction sensing of a gradient at a single cell level.

Description

Keywords

q-bio.CB, q-bio.CB, physics.bio-ph, 92C17

Journal Title

Scientific Reports

Conference Name

Journal ISSN

2045-2322
2045-2322

Volume Title

8

Publisher

Nature Publishing Group
Sponsorship
Wellcome Trust (105602/Z/14/Z)
Engineering and Physical Sciences Research Council (EP/K032208/1)
This work was supported by EPSRC grant no EP/K032208/1. U.D. was supported by a Junior Interdisciplinary Fellowship via Wellcome Trust grant number 105602/Z/14/Z and a Herchel Smith Postdoctoral Fellowship. D.H. team is supported by a FRM grant.