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Atypical, non-standard functions of the microtubule associated Tau protein.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Sotiropoulos, Ioannis  ORCID logo  https://orcid.org/0000-0003-0115-0038
Galas, Marie-Christine 
Silva, Joana M 
Skoulakis, Efthimios 
Wegmann, Susanne 

Abstract

Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.

Description

Keywords

Alzheimer’s disease, Dendrites, Neuronal function, Nucleus, Pathology, Subcellular localization, Synapse, Tau, Tau isoform, Alzheimer Disease, Animals, Humans, tau Proteins

Journal Title

Acta Neuropathol Commun

Conference Name

Journal ISSN

2051-5960
2051-5960

Volume Title

5

Publisher

Springer Science and Business Media LLC