The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration.
Published version
Peer-reviewed
Repository URI
Repository DOI
Type
Change log
Authors
Abstract
Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent trans-diagnostic approaches that span the spectrum of clinical presentations of FTLD and parkinsonism, indicate that apathy and impulsivity can be fractionated into multiple neuroanatomical and pharmacological systems. These include ventral/dorsal fronto-striatal circuits for reward-sensitivity, response-inhibition, and decision-making; moderated by noradrenaline, dopamine, and serotonin. Improved assessment tools, formal models of cognition and behavior, combined with brain imaging and psycho-pharmacology, are creating new therapeutic targets and establishing principles for stratification in future clinical trials.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
2352-1546
Volume Title
Publisher
Publisher DOI
Sponsorship
Wellcome Trust (103838/Z/14/Z)
James S McDonnell Foundation (220020289)
Medical Research Council (MC_U105597119)
Medical Research Council (MC_UU_00005/12)