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Testicular cancer in 2017: Sequencing advances understanding.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Murray, Matthew J 
Turnbull, Clare 

Abstract

Our biological understanding of TGCTs has been improved using sequencing, and molecular profiles associated with the genomic evolution and development of cisplatin resistance have been identified. The genomics of variants underpinning TGCT predisposition is being delineated. Studies of circulating microRNAs have demonstrated their potential for noninvasive diagnosis and disease monitoring.

Description

Keywords

Biomarkers, Tumor, Drug Resistance, Neoplasm, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Male, MicroRNAs, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Exome Sequencing

Journal Title

Nat Rev Urol

Conference Name

Journal ISSN

1759-4812
1759-4820

Volume Title

15

Publisher

Springer Science and Business Media LLC
Sponsorship
Isaac Newton Trust (1540 (f))
St Baldrick's Foundation (via Dana-Farber Cancer Institute) (2015-0743)