Broad Chromatin Domains: An Important Facet of Genome Regulation.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Carelli, Francesco N https://orcid.org/0000-0003-4280-4923
Sharma, Garima https://orcid.org/0000-0001-8698-3682
Ahringer, Julie https://orcid.org/0000-0002-7074-4051
Abstract
Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans.
Description
Keywords
H3K27me3, PRC2, chromatin domain, histone modifications, Animals, Caenorhabditis elegans, Chromatin, Chromatin Assembly and Disassembly, Chromatin Immunoprecipitation, Drosophila melanogaster, Epigenesis, Genetic, Genome, Histones, Lysine, Methylation, Mice, Promoter Regions, Genetic, Protein Processing, Post-Translational
Journal Title
Bioessays
Conference Name
Journal ISSN
0265-9247
1521-1878
1521-1878
Volume Title
39
Publisher
Wiley
Publisher DOI
Sponsorship
Wellcome Trust (101863/Z/13/Z)
Royal Society (NF160767)
Royal Society (NF160767)