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Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

Published version
Peer-reviewed

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Authors

Martincorena, Inigo 
Young, Matthew D 
Foroni, Letizia 
Bolli, Niccolo 

Abstract

Mutations affecting key modifiable histone type 3 (H3; Supplementary Table 1) residues are frequent oncogenic events in certain solid tumours (Feinberg, et al 2016), and have also recently been implicated in a subset of acute myeloid leukaemia (AML)(Lehnertz, et al 2017). Here, we systematically reviewed the somatic mutations in >20,000 cancer specimens to identify tumours harbouring H3 mutations. In a subset of T-cell acute lymphoblastic leukaemia (T-ALL) we identified non-methionine mutations of the key modifiable H3 residues, lysine (K) 27 and 36.

Description

Keywords

acute leukaemia, aetiology, cancer genetics, haematological malignancy, Cell Line, Tumor, Histones, Humans, Mutation, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Journal Title

Br J Haematol

Conference Name

Journal ISSN

0007-1048
1365-2141

Volume Title

184

Publisher

Wiley
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC 2012-2017)
Medical Research Council (MC_PC_12009)
Cancer Research UK (23015)