cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway.
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Peer-reviewed
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Abstract
The nitric oxide (NO)-protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct size in patients have failed in the past, the advent of novel drugs that modulate cGMP and its downstream targets shows very promising results in recent preclinical and clinical studies. Here, we review main aspects of the NO-PKG pathway in light of recent drug development and summarise potential cardioprotective strategies in which cGMP is the main player.
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Keywords
Cardioprotection, Ischaemia/reperfusion, cGMP, Animals, Cardiovascular Agents, Cyclic GMP, Cyclic GMP-Dependent Protein Kinases, Enzyme Activation, Enzyme Activators, Heart Failure, Humans, Myocardial Reperfusion Injury, Myocardium, Nitric Oxide, Signal Transduction
Journal Title
Basic Res Cardiol
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Journal ISSN
0300-8428
1435-1803
1435-1803
Volume Title
113
Publisher
Springer Science and Business Media LLC