RIPK1 promotes inflammation and β-amyloid accumulation in Alzheimer's disease.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Rubinsztein, David C
Abstract
Alzheimer’s disease (AD), the leading cause of dementia, is a major cause of death and a significant economic burden. In 2016, ∼700,000 Americans aged 65 and over died of AD, and the total health and social care payments for AD in the United States alone exceeded $230 billion (1). Currently, there are no validated disease-modifying therapies that slow the progression of human AD.
Description
Keywords
Alzheimer Disease, Amyloid beta-Peptides, Inflammation, Peptide Fragments
Journal Title
Proc Natl Acad Sci U S A
Conference Name
Journal ISSN
0027-8424
1091-6490
1091-6490
Volume Title
114
Publisher
Proceedings of the National Academy of Sciences
Publisher DOI
Sponsorship
Wellcome Trust (100140/Z/12/Z)
Wellcome Trust (095317/Z/11/Z)
Wellcome Trust (095317/Z/11/Z)