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Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila.

Published version
Peer-reviewed

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Abstract

Successful neurogenesis requires adequate proliferation of neural stem cells (NSCs) and their progeny, followed by neuronal differentiation, maturation and survival. NSCs inhabit a complex cellular microenvironment, the niche, which influences their behaviour. To ensure sustained neurogenesis, niche cells must respond to extrinsic, environmental changes whilst fulfilling the intrinsic requirements of the neurogenic program and adapting their roles accordingly. However, very little is known about how different niche cells adjust their properties to such inputs. Here, we show that nutritional and NSC-derived signals induce the remodelling of Drosophila cortex glia, adapting this glial niche to the evolving needs of NSCs. First, nutrition-induced activation of PI3K/Akt drives the cortex glia to expand their membrane processes. Second, when NSCs emerge from quiescence to resume proliferation, they signal to glia to promote membrane remodelling and the formation of a bespoke structure around each NSC lineage. The remodelled glial niche is essential for newborn neuron survival.

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Keywords

D. melanogaster, developmental biology, glia, neural stem cell, neurogenesis, neuron, niche, stem cells, Animals, Cell Communication, Cell Differentiation, Cell Proliferation, Drosophila, Immunohistochemistry, Neural Stem Cells, Neurogenesis, Neuroglia

Journal Title

Elife

Conference Name

Journal ISSN

2050-084X
2050-084X

Volume Title

7

Publisher

eLife Sciences Publications, Ltd
Sponsorship
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (092545/Z/10/Z)
Wellcome Trust (103792/Z/14/Z)
Cancer Research Uk (None)