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Genetic susceptibility.

Accepted version
Peer-reviewed

Type

Article

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Authors

Marciniak, Stefan J 
Lomas, David A 

Abstract

Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component. The combination of genome-wide association studies and candidate gene analysis is helping to identify those genetic variants responsible for an individual's susceptibility to developing COPD. In this review, the current data implicating specific loci and genes in the pathogenesis of COPD are examined.

Description

Keywords

COPD, Emphysema, GWAS, Genetics, SNP, Disease Susceptibility, Elastin, Extracellular Matrix, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Mutation, Peptide Hydrolases, Protease Inhibitors, Pulmonary Disease, Chronic Obstructive, Reactive Oxygen Species, alpha 1-Antitrypsin

Journal Title

Clin Chest Med

Conference Name

Journal ISSN

0272-5231
1557-8216

Volume Title

35

Publisher

Elsevier BV
Sponsorship
Medical Research Council (G1002610)
Medical Research Council (G0901786)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)