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Fibrinogen does not relate to cardiovascular or muscle manifestations in chronic obstructive pulmonary disease (COPD): cross-sectional data from the ERICA study

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Peer-reviewed

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Authors

Wilkinson, IB 

Abstract

Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator – fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction force (QMVC) and fibrinogen were measured in 729, stable, GOLD stage II-IV COPD patients. The cardiovascular and muscular manifestations exist independently (p=0.22, Chi squared). Fibrinogen was not associated with aPWV or QMVC (p=0.628 and p=0.621 respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.

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BMJ

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Department of Health (via National Institute for Health Research (NIHR)) (unknown)
National Institute for Health Research (NIHR) (via Cambridgeshire and Peterborough Clinical Commissioning Group (CCG)) (unknown)
Technology Strategy Board (101024 TP 9157-61188)
NIHR West Anglia Comprehensive Local Research Network (CLRN) (via Cambridge University Hospitals NHS Foundation Trust (CUH)) (CLRN ERICA)
National Institute for Health Research (NIHR) (via West Anglia Comprehensive Local Research Network (CLRN)) (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)