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Correlated multistate models for multiple processes: an application to renal disease progression in systemic lupus erythematosus.

Published version
Peer-reviewed

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Authors

O'Keeffe, Aidan G 
Farewell, Vernon T 

Abstract

Bidirectional changes over time in the estimated glomerular filtration rate and in urine protein content are of interest for the treatment and management of patients with lupus nephritis. Although these processes may be modelled by separate multistate models, the processes are likely to be correlated within patients. Motivated by the lupus nephritis application, we develop a new multistate modelling framework where subject-specific random effects are introduced to account for the correlations both between the processes and within patients over time. Models are fitted by using bespoke code in standard statistical software. A variety of forms for the random effects are introduced and evaluated by using the data from the Systemic Lupus International Collaborating Clinics.

Description

Keywords

Continuous time Markov model, Multistate model, Multivariate longitudinal data, Random effects

Journal Title

J R Stat Soc Ser C Appl Stat

Conference Name

Journal ISSN

0035-9254
1467-9876

Volume Title

67

Publisher

Oxford University Press (OUP)
Sponsorship
MRC (unknown)
Medical Research Council (MR/M025152/1)