jats:p Do macropsychological factors predict “hard” economic outcomes like regional economic resilience? Prior approaches to understanding economic resilience have focused on regional economic infrastructure. In contrast, we draw on research highlighting the key role played by psychological factors in economic behaviors. Using large psychological data sets from the United States ( n = 935,858) and Great Britain ( n = 417,217), we characterize region-level psychological correlates of economic resilience. Specifically, we examine links between regions’ levels of psychological traits and their degree of economic slowdown (indexed by changes in entrepreneurial vitality) in the wake of the Great Recession of 2008–2009. In both countries, more emotionally stable regions and regions with a more prevalent entrepreneurial personality makeup showed a significantly lower economic slowdown. This effect was robust when accounting for regional differences in economic infrastructure. Cause cannot be inferred from these correlational findings, but the results nonetheless point to macropsychological factors as potentially protective factors against macroeconomic shocks. </jats:p>