Clinical Evaluation of 2 Point-of-Care Lateral Flow Tests for the Diagnosis of Syphilis.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Nakku-Joloba, Edith
Kiragga, Agnes
Mbazira, Joshua Kimeze
Kambugu, Fred
Jett-Goheen, Mary
Abstract
A diagnostic performance study comparing the only Food and Drug Administration-approved, point-of-care (POC) treponemal test (Syphilis Health Check) and the World Health Organization pre-qualified SD Bioline POC treponemal test against a treponemal hemagglutination test (TPHA) and a sequential algorithm of nontreponemal rapid plasma reagin and TPHA found both POC tests had >85% sensitivity compared with the TPHA and >85% sensitivity and >95% specificity compared with the rapid plasma reagin and TPHA standards.
Description
Keywords
Adult, Algorithms, Antibodies, Bacterial, Cross-Sectional Studies, Female, Hemagglutination Tests, Humans, Male, Point-of-Care Systems, Reagins, Sensitivity and Specificity, Syphilis, Syphilis Serodiagnosis, Treponema pallidum, Young Adult
Journal Title
Sex Transm Dis
Conference Name
Journal ISSN
0148-5717
1537-4521
1537-4521
Volume Title
43
Publisher
Ovid Technologies (Wolters Kluwer Health)