Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Published version
Peer-reviewed
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Repository DOI
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Authors
Soond, Dalya R
Slack, Elizabeth CM
Garden, Oliver A
Patton, Daniel T
Okkenhaug, Klaus https://orcid.org/0000-0002-9432-4051
Abstract
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some studies suggest that inhibition of the PI3K pathway is essential for the development of Tregs whereas other studies have shown reduced Treg numbers and function when PI3K activity is suppressed. Here we attempt to reconcile the different studies that have explored PI3K and the downstream effectors Akt, Foxo, and mTOR in regulatory T cell development and function and discuss the implications for health and therapeutic intervention.
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Keywords
Akt, Foxo, PI3K, T cell, Treg, autoimmunity, inflammation, mTOR
Journal Title
Front Immunol
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Journal ISSN
1664-3224
1664-3224
1664-3224
Volume Title
3
Publisher
Frontiers Media SA