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Prevalence of neurogenetic disorders in the North of England.

Published version
Peer-reviewed

Type

Article

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Authors

Bargiela, David 
Yu-Wai-Man, Patrick 
Keogh, Michael 
Chinnery, Patrick F 

Abstract

OBJECTIVE: Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence. METHODS: Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England. RESULTS: Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6-94.3), or 1 in 1,100 of the population in Northern England. CONCLUSION: As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery.

Description

Keywords

England, Genetic Predisposition to Disease, Humans, Mitochondrial Diseases, Movement Disorders, Mutation, Nervous System Diseases, Prevalence

Journal Title

Neurology

Conference Name

Journal ISSN

0028-3878
1526-632X

Volume Title

85

Publisher

Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Wellcome Trust (101876/Z/13/Z)