Prevalence of neurogenetic disorders in the North of England.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bargiela, David
Yu-Wai-Man, Patrick
Keogh, Michael
Horvath, Rita https://orcid.org/0000-0002-9841-170X
Chinnery, Patrick F
Abstract
OBJECTIVE: Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence. METHODS: Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England. RESULTS: Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6-94.3), or 1 in 1,100 of the population in Northern England. CONCLUSION: As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery.
Description
Keywords
England, Genetic Predisposition to Disease, Humans, Mitochondrial Diseases, Movement Disorders, Mutation, Nervous System Diseases, Prevalence
Journal Title
Neurology
Conference Name
Journal ISSN
0028-3878
1526-632X
1526-632X
Volume Title
85
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
Sponsorship
Wellcome Trust (101876/Z/13/Z)