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Simultaneous confidence sets for several effective doses.

Accepted version
Peer-reviewed

Type

Article

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Authors

Tompsett, Daniel M 
Biedermann, Stefanie  ORCID logo  https://orcid.org/0000-0001-8900-8268
Liu, Wei 

Abstract

Construction of simultaneous confidence sets for several effective doses currently relies on inverting the Scheffé type simultaneous confidence band, which is known to be conservative. We develop novel methodology to make the simultaneous coverage closer to its nominal level, for both two-sided and one-sided simultaneous confidence sets. Our approach is shown to be considerably less conservative than the current method, and is illustrated with an example on modeling the effect of smoking status and serum triglyceride level on the probability of the recurrence of a myocardial infarction.

Description

Keywords

effective dose, inverse dose response curve, logistic regression, simultaneous confidence band, simultaneous inference, Biometry, Confidence Intervals, Humans, Models, Statistical, Myocardial Infarction, Smoking, Triglycerides

Journal Title

Biom J

Conference Name

Journal ISSN

0323-3847
1521-4036

Volume Title

60

Publisher

Wiley