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A graph theoretical approach to data fusion.

Published version
Peer-reviewed

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Authors

Žurauskienė, Justina 
Kirk, Paul DW 
Stumpf, Michael PH 

Abstract

The rapid development of high throughput experimental techniques has resulted in a growing diversity of genomic datasets being produced and requiring analysis. Therefore, it is increasingly being recognized that we can gain deeper understanding about underlying biology by combining the insights obtained from multiple, diverse datasets. Thus we propose a novel scalable computational approach to unsupervised data fusion. Our technique exploits network representations of the data to identify similarities among the datasets. We may work within the Bayesian formalism, using Bayesian nonparametric approaches to model each dataset; or (for fast, approximate, and massive scale data fusion) can naturally switch to more heuristic modeling techniques. An advantage of the proposed approach is that each dataset can initially be modeled independently (in parallel), before applying a fast post-processing step to perform data integration. This allows us to incorporate new experimental data in an online fashion, without having to rerun all of the analysis. We first demonstrate the applicability of our tool on artificial data, and then on examples from the literature, which include yeast cell cycle, breast cancer and sporadic inclusion body myositis datasets.

Description

Keywords

Algorithms, Bayes Theorem, Computational Biology, Databases, Genetic, Genomics, Humans, Models, Theoretical, Saccharomyces cerevisiae

Journal Title

Stat Appl Genet Mol Biol

Conference Name

Journal ISSN

2194-6302
1544-6115

Volume Title

15

Publisher

Walter de Gruyter GmbH