Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Lima, Fabio https://orcid.org/0000-0003-2127-9568
Grunenberg, Lars
Rahman, Husaini BA
Labes, Ricardo https://orcid.org/0000-0003-4001-0775
Sedelmeier, Joerg
Abstract
We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.
Description
Keywords
0305 Organic Chemistry
Journal Title
Chem Commun (Camb)
Conference Name
Journal ISSN
1359-7345
1364-548X
1364-548X
Volume Title
54
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)