Linking axon transport to regeneration using in vitro laser axotomy.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Nieuwenhuis, Bart https://orcid.org/0000-0002-2065-2271
Eva, Richard https://orcid.org/0000-0003-0305-0452
Abstract
Spinal cord injury has devastating consequences because adult central nervous system (CNS) neurons do not regenerate their axons after injury. Two key reasons for axon regeneration failure are extrinsic inhibitory factors and a low intrinsic capacity for axon regrowth. Research has therefore focused on overcoming extrinsic growth inhibition, and enhancing intrinsic regeneration capacity. Both of these issues will need to be addressed to enable optimal repair of the injured spinal cord.
Description
Keywords
32 Biomedical and Clinical Sciences, 3209 Neurosciences
Journal Title
Neural Regen Res
Conference Name
Journal ISSN
1673-5374
1876-7958
1876-7958
Volume Title
13
Publisher
Medknow
Publisher DOI
Sponsorship
Medical Research Council (MR/R004463/1)
Medical Research Council (G1000864)
Medical Research Council (MR/R004544/1)
Spinal Research (ISRT) (NRB110)
MRC (G1000864)
Medical Research Council (G1000864)
Medical Research Council (MR/R004544/1)
Spinal Research (ISRT) (NRB110)
MRC (G1000864)