Repository logo
 

Hereditary selective cobalamin malabsorption and concurrent pancreatitis in a young Border collie

Accepted version
Peer-reviewed

Loading...
Thumbnail Image

Type

Article

Change log

Authors

McCallum, KE 
Watson, PJ 

Abstract

A one-year-old neutered male Border collie presented with failure to gain weight, lethargy, intermittent leucopenia, borderline anaemia and intermittent gastrointestinal symptoms. He was diagnosed with pancreatitis based on blood results and abdominal ultrasonography and hereditary selective cobalamin malabsorption based on hypocobalaminaemia, methylmalonic aciduria and genetic testing for cubilin mutation. The dog responded to oral cobalamin supplementation with resolution of clinical signs and normalisation of serum cobalamin. There was no recurrence of signs after 27 months of follow-up. An association between organic acidaemias and pancreatitis has been reported in humans but to the authors' knowledge, this is the first report of hereditary selective cobalamin malabsorption and concurrent pancreatitis in a dog. Furthermore, this is the first report of inherited canine cobalamin deficiency responding to oral cobalamin supplementation.

Description

Keywords

pancreas, vitamin deficiency, dog

Journal Title

Veterinary Record Case Reports

Conference Name

Journal ISSN

2052-6121
2052-6121

Volume Title

6

Publisher

BMJ
Sponsorship
This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.