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Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Sun, Yi-Qian 
Brumpton, Ben M 
Bonilla, Carolina 
Lewis, Sarah J 
Burgess, Stephen 

Abstract

We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93-1.06) per allele score. A 25 nmol·L-1 increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54-1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.

Description

Keywords

Adult, Aged, Alleles, Female, Genetic Predisposition to Disease, Humans, Incidence, Linear Models, Lung Neoplasms, Male, Mendelian Randomization Analysis, Middle Aged, Norway, Polymorphism, Single Nucleotide, Prospective Studies, Registries, Vitamin D

Journal Title

Eur Respir J

Conference Name

Journal ISSN

0903-1936
1399-3003

Volume Title

51

Publisher

European Respiratory Society (ERS)
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MR/L003120/1)
British Heart Foundation (None)
Medical Research Council (MC_UU_00002/7)