Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp 3 )−H Activation
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Zakrzewski, J
Smalley, AP
Kabeshov, MA
Gaunt, MJ
Lapkin, AA
Abstract
A continuous‐flow synthesis of aziridines by palladium‐catalyzed C(sp3)−H activation is described. The new flow reaction could be combined with an aziridine‐ring‐opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C−H activation flow process and illustrates an approach towards first‐principles design based on novel catalytic reactions.
Description
Keywords
C−H activation, aziridines, continuous-flow synthesis, palladium catalysis, ring opening
Journal Title
Angewandte Chemie
Conference Name
Journal ISSN
1433-7851
1521-3773
1521-3773
Volume Title
55
Publisher
Wiley
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/I00548X/1)
We are grateful to the Department of Chemical Engineering and Biotechnology (J.Z.) and the EPSRC (A.P.S.) for studentships, and to the ERC and EPSRC (EP/100548X/1) for fellowships (M.J.G.). Mass spectroscopy data were acquired at the EPSRC UK National Mass Spectroscopy Facility at Swansea University