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Classic Models for New Perspectives: Delving into Helminth-Microbiota-Immune System Interactions.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Cortés, Alba 
Toledo, Rafael 

Abstract

Whilst a wealth of data indicate that infections by gastrointestinal helminths are accompanied by significant alterations in the composition of the vertebrate gut flora, little is known of the immune-molecular mechanisms that regulate host-parasite-microbiota interactions. 'Traditional' experimental models of gastrointestinal helminthiases, in which the role(s) of each of the components of this triad can be tested, provide an opportunity to advance research in this area. In this article, we propose the Echinostoma caproni-mouse system as a potentially useful tool for studies of the role of the host gut microbiota in preventing pathology and inducing parasite clearance via interleukin (IL)-25, an epithelial-derived alarmin with key roles in antihelminth immunity and maintenance of gut homeostasis.

Description

Keywords

Echinostoma caproni, experimental model, gut, interleukin (IL)-25, macrobiota, microbiota, Animals, Helminthiasis, Host-Parasite Interactions, Humans, Models, Biological

Journal Title

Trends Parasitol

Conference Name

Journal ISSN

1471-4922
1471-5007

Volume Title

34

Publisher

Elsevier BV