Deconstructing and reconstructing the mouse and human early embryo.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Shahbazi, Marta N https://orcid.org/0000-0002-1599-5747
Zernicka-Goetz, Magdalena https://orcid.org/0000-0002-7004-2471
Abstract
The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
Description
Keywords
Animals, Cell Lineage, Cells, Cultured, Embryo Research, Embryo, Mammalian, Gene Expression Regulation, Developmental, Gestational Age, History, 20th Century, History, 21st Century, Human Embryonic Stem Cells, Humans, Mice, Morphogenesis, Mouse Embryonic Stem Cells, Signal Transduction, Stem Cell Research
Journal Title
Nat Cell Biol
Conference Name
Journal ISSN
1465-7392
1476-4679
1476-4679
Volume Title
20
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Wellcome Trust (098287/Z/12/Z)
European Research Council (669198)
Isaac Newton Trust (17.08(p))
Leverhulme Trust (ECF-2017-285)
European Research Council (669198)
Isaac Newton Trust (17.08(p))
Leverhulme Trust (ECF-2017-285)
European Research Council (669198)
Wellcome Trust (098287/Z/12/Z)
Early Career Leverhulme Trust fellowship.