Mitochondrial function in thoracic aortic aneurysms
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Mitochondria contain multiple copies of mitochondrial DNA (mtDNA) that encode ribosomal and transfer RNAs and many essential proteins required for oxidative phosphorylation. Mitochondria are essential for generation of ATP, but also generate reactive oxygen species (ROS) as a by-product of the electron transport chain. Oxidative damage to mitochondrial DNA induces respiratory chain dysfunction, resulting in reduced ATP synthesis and further increased ROS generation. The reduced mitochondrial respiration may be accompanied by increased glycolysis and increased lactate production, and these changes can be detected by reduced oxygen consumption and increased extracellular pH of tissues or cultured cells. Mitochondrial dysfunction leading to reduced mitochondrial respiration has been implicated in both normal vascular ageing and a variety of cardiovascular diseases,, including atherosclerosis, heart failure, and aneurysm formation. For example, reduced mitochondrial DNA (mtDNA) copy number, mitochondrial respiration and expression of specific electron transport chain complexes has been shown in vascular smooth muscle cells (VSMCs) derived from human atherosclerotic plaques1-3. Mitochondriogenesis and mitophagy are also important regulators of mitochondrial health and number. ROS induce VSMC mitophagy, and similarly plaque VSMCs show increased mitophagy compared with normal arterial VSMCs2.
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1755-3245
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British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation (PG/16/11/32021)
British Heart Foundation (PG/16/63/32307)
British Heart Foundation (CH/2000003)
British Heart Foundation (PG/16/24/32090)
British Heart Foundation (None)