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A Toolbox for Discrete Modelling of Cell Signalling Dynamics

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Paterson, Yasmin Z 
Pleijzier, Markus W 
Piterman, Nir 
Bendtsen, Claus 

Abstract

In an age where the volume of data regarding biological systems exceeds our ability to analyse it, many researchers are looking towards systems biology and computational modelling to help unravel the complexities of gene and protein regulatory networks. In order to make such techniques more accessible to mainstream researchers, tools such as the BioModelAnalyzer (BMA) have been developed to provide a user-friendly graphical interface for discrete modelling of biological systems. Here we use the BMA to build a library of target functions of known molecular interactions, translated from ordinary differential equations (ODEs). We then show that these BMA target functions can be used to reconstruct complex networks, which can correctly predict many known genetic perturbations. This new library supports the accessibility ethos behind the creation of BMA, providing a toolbox for the construction of complex cell signalling models without the need for extensive experience in computer programming or mathematical modelling, and allows for construction and simulation of complex biological systems with only small amounts of quantitative data.

Description

Keywords

Cell Cycle, Computational Biology, Computer Simulation, Gene Regulatory Networks, Homeostasis, Humans, Models, Biological, Oscillometry, Signal Transduction, Software, Systems Biology

Journal Title

Integrative Biology (United Kingdom)

Conference Name

Journal ISSN

1757-9694
1757-9708

Volume Title

Volume 10

Publisher

Oxford University Press (OUP)
Sponsorship
Royal Society (Paul Instrument Fund) (UF130039)
MRC (unknown)
Medical Research Council (MC_UU_12022/9)
MRC
Biotechnology and Biological Sciences Research Council (1804772)
Royal Society