Structure and mechanism of bacterial tripartite efflux pumps.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Neuberger, Arthur https://orcid.org/0000-0002-7744-6559
Du, Dijun https://orcid.org/0000-0002-1546-8939
Luisi, Ben F
Abstract
Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic membrane fusion protein. These tripartite machineries span both membranes and the periplasmic space, and they extrude from the bacterium chemically diverse toxic substrates. In this chapter, we summarise current understanding of the structural architecture, functionality, and regulation of tripartite multi-drug efflux assemblies.
Description
Keywords
Antibiotic resistance, Membrane proteins, Multi-drug efflux pumps, Tripartite assemblies, Bacterial Proteins, Gram-Negative Bacteria, Membrane Transport Proteins, Models, Molecular, Protein Conformation
Journal Title
Res Microbiol
Conference Name
Journal ISSN
0923-2508
1769-7123
1769-7123
Volume Title
169
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Human Frontier Science Program (HFSP) (RPG0034/2013)
European Research Council (742210)
European Research Council (742210)
ERC